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Botox Injection Sites: Facial and Body Botox Treatment Areas

May 23, 2025
Written by
Dr. Dylan Cahill, MD

Botox Cosmetic has become a go-to solution for those looking to smooth fine lines, soften wrinkles, and achieve a more youthful appearance. While it’s most commonly associated with facial treatments, Botox is far more versatile than many realize. It can be used to enhance and revitalize various areas of the face and even certain parts of the body. In this article, we’ll review the most common Botox injection sites, how they work, and the aesthetic benefits they provide.

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Read more: Comparing 5 Different Types of Botox Brands

Botox Injection Sites for the Face in General

Botox is primarily known for its ability to treat fine lines and wrinkles on the face, creating a smoother and more youthful appearance. Here are the most common areas where Botox is used for facial aesthetics:

Forehead Lines

Horizontal lines that form across the forehead due to expressions like raising your eyebrows. Botox relaxes these muscles, reducing the appearance of lines and preventing them from deepening over time.

Glabellar Lines (Frown Lines)

These are the vertical lines that appear between the eyebrows, often called “11 lines.” Botox smooths these creases, giving a more relaxed and refreshed look.

Crow’s Feet

The fine lines that appear at the outer corners of the eyes when smiling or squinting. Botox helps soften these lines, making the eye area look more youthful.

Bunny Lines

Wrinkles that form on the sides of the nose when you scrunch it. A few units of Botox can smooth out these fine lines.

Lip Lines (Smoker’s Lines)

Vertical lines that develop around the lips, often more noticeable in smokers or those who frequently purse their lips. Botox can soften these lines for a smoother appearance.

Marionette Lines

Lines that run from the corners of the mouth down toward the chin, creating a frown-like appearance. While typically treated with fillers, Botox can sometimes be used to soften the area.

Chin Dimpling (Orange Peel Chin)

Botox can be used to smooth out the dimpled or “orange peel” texture that sometimes appears on the chin.

Jawline Contouring (Masseter Reduction)

For those who want a slimmer jawline or relief from teeth grinding, Botox can be injected into the masseter muscles to relax them, creating a more contoured appearance.

Neck Bands (Platysmal Bands)

These vertical lines or bands in the neck can be softened with Botox, helping to create a smoother and more youthful neck profile.

Botox Injection Sites for the Upper Face

Botox for Forehead Wrinkles

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Forehead lines are among the most common areas treated with Botox. These horizontal lines form as a result of repetitive movements of the frontalis muscle, which raises the eyebrows. Botox is injected directly into this muscle to relax it, softening the appearance of lines and preventing new ones from forming.

The typical dosage for treating forehead wrinkles ranges from 12 to 20 units of Botox, depending on the severity of the lines and individual muscle strength. The goal is to achieve a smoother, more youthful appearance while maintaining some natural movement. This balance is essential to avoid the “frozen” look and is best achieved by an experienced injector who understands facial anatomy.

Like for all areas treated with Botox, results generally begin to appear within 5 to 7 days, with full effects visible by two weeks. Regular treatments every three to four months can help maintain a smoother forehead and prevent deeper lines from setting in over time.

Botox Injection Sites for Crow’s Feet

Crow’s feet are the fine lines that form at the outer corners of the eyes, primarily due to smiling, squinting, and natural aging. These lines are some of the first to appear as they are in an area where the skin is thin and more susceptible to movement.

To treat crow’s feet, Botox is injected into the orbicularis oculi muscle, which is responsible for eye closure. This reduces the muscle’s movement, smoothing out the lines while still allowing for natural expression. Typical Botox dosage for this area ranges from 12 to 40 units, depending on the depth of the wrinkles and individual muscle activity.

Botox for Frown Lines (Glabellar Lines) Between the Eyebrows

Frown lines, also known as glabellar lines or “11 lines,” are the vertical wrinkles that form between the eyebrows as a result of repeated muscle contractions. These lines become more noticeable with age and can give the face a tired or angry appearance even when you are relaxed. Botox effectively smooths these lines by relaxing the underlying muscles, primarily the corrugator and procerus muscles.

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The typical dosage for glabellar lines ranges from 15 to 25 units, depending on the depth of the wrinkles and the strength of the muscles involved. Injections are placed at specific points in the center of the forehead and around the brows, including the corrugator supercilia and procerus muscles, to achieve a balanced, natural look.

Bunny Lines Botox Injection Sites for Nose Wrinkles

Bunny lines are the fine wrinkles that form on either side of the nose when you scrunch it, usually while laughing or smiling. These lines tend to become more pronounced over time and can be especially noticeable when facial expressions are exaggerated.

Botox is injected into the nasalis muscle, which is responsible for creating these lines. Typically, a small dose of around 5 to 10 units is used, divided into precise injection sites along the sides of the nose. The goal is to relax the muscle enough to smooth the lines without affecting your natural expressions. Because only a small amount of Botox is required, the risk of affecting other facial movements is minimal.

Eyebrow Lift with Botox Botox Injection Sites for a Subtle Lift

An eyebrow lift with Botox is a non-surgical way to achieve a more lifted and refreshed appearance around the eyes. This treatment is ideal for those who want to open up their eye area without the need for surgery. Botox is injected into the muscles that pull the eyebrows downward, such as the orbicularis oculi and parts of the frontalis. By relaxing these muscles, the muscles that elevate the brows can work more effectively, resulting in a subtle yet noticeable lift.

The typical injection sites include the outer corners of the brows and occasionally the middle of the forehead, depending on individual anatomy. This technique not only lifts the brows but also smooths out fine lines in the area, creating a rejuvenated and alert look. At ZENA Aesthetics & Wellness in Bradenton, FL, we customize each eyebrow lift to ensure it enhances your natural features while maintaining facial harmony.

Botox for Hooded Eyes Raising the Eyebrows for a More Open Look

For individuals with hooded eyes, Botox can be an effective solution to create a more open and awake appearance. Hooded eyes occur when excess skin folds over the upper eyelid, sometimes making the eyes look smaller or more tired. Botox is injected around the brow area to lift the eyelids gently, reducing the heaviness and giving the eyes a brighter look.

The injections are placed in specific points near the lateral brows and sometimes in the glabellar region to optimize the lift. This treatment helps smooth out drooping skin and elevate the brows slightly, making the eyes appear larger and more refreshed. Unlike surgery, the results are temporary but can be maintained with regular treatments.

Botox Injection Sites for the Lower Face

Botox for Lipstick Lines and Smile Lines Around the Mouth

Lipstick lines, also known as “smoker’s lines” or perioral lines, are the fine vertical wrinkles that appear around the lips. These lines become more prominent with age and repetitive lip movements, even for non-smokers. Botox is injected into the orbicularis oris muscle, which encircles the mouth, to relax the muscle activity that causes these lines. Typically, a very small amount of Botox is used in this area to avoid impacting natural lip movement, while still smoothing the fine lines.

For smile lines, which are also called nasolabial folds, Botox is sometimes used in combination with fillers for optimal results. While Botox alone does not significantly reduce the depth of smile lines, it can soften the muscle movement that contributes to them. At ZENA Aesthetics & Wellness, we assess the depth and structure of your smile lines to create a customized plan, sometimes combining Botox with Juvéderm or Restylane filler for a more complete result.

Botox for Chin Dimpling

Chin dimpling, also known as “orange peel chin,” occurs when the mentalis muscle contracts, creating a textured or uneven appearance on the chin. This can become more noticeable with age as collagen decreases and skin elasticity diminishes. Botox can be used to relax the mentalis muscle, smoothing out the surface of the chin and providing a more youthful contour.

Injections are placed in the central and lower parts of the chin to target the areas where dimpling is most apparent. This technique is highly effective for creating a softer, more balanced look, especially when paired with other treatments like fillers to enhance volume.

Botox for Jawline Slimming Injection Sites for a Defined Jaw

Botox is increasingly used for jawline slimming and contouring, offering a non-surgical option to achieve a more defined and sculpted look. This treatment is particularly effective for individuals with an enlarged masseter muscle, which can create a square or bulky jawline. Botox is injected directly into the masseter muscles on each side of the face to relax them. Over time, this relaxation reduces muscle size, resulting in a slimmer, more contoured jawline.

The typical dosage ranges from 20 to 50 units per side, depending on the individual’s muscle strength and desired outcome. Results begin to appear within a few weeks and can last anywhere from three to six months. Regular treatments help maintain a slimmer appearance and may even reduce issues like teeth grinding (bruxism) for some patients.

Botox for Neck Lines and Bands

As we age, horizontal neck lines and vertical platysmal bands can become more pronounced, giving the neck an aged appearance. Botox is an effective treatment for softening these lines and tightening the neck area without surgery. Injections are placed along the neck bands and lines to relax the platysma muscle, which is responsible for creating these visible signs of aging.

The treatment smooths out the appearance of horizontal neck lines and reduces the prominence of vertical bands, making the neck look firmer and more youthful. Botox can also help prevent further deepening of lines by minimizing repetitive muscle movements.

Other Botox Injection Sites for Full-Body Aesthetics

Botox for Jaw Angle Treatment for Teeth Grinding (Bruxism)

Bruxism, or teeth grinding, is a condition where individuals unconsciously clench or grind their teeth, often during sleep. This can lead to headaches, jaw pain, and even damage to teeth. Botox is an effective, non-surgical treatment for managing bruxism by relaxing the masseter muscles responsible for the grinding action.

Botox injections are administered into the masseter muscles on both sides of the face and sometimes the temporalis muscles. This reduces their activity, alleviating tension and preventing the grinding and clenching that contribute to discomfort and dental issues. An added benefit of this treatment is a slimmer jawline, as the muscles naturally reduce in size over time with less strain. Most patients notice relief from symptoms within a few days, with full results appearing around two weeks post-treatment.

Botox for Gummy Smile Correction

A gummy smile occurs when too much of the upper gums are exposed when smiling. This can be due to overactive muscles around the upper lip that cause it to lift higher than desired. Botox provides a simple and effective solution for this by relaxing the hyperactive muscles, allowing the upper lip to rest in a slightly lower position when smiling.

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The injections are placed precisely at points along the upper lip, targeting the levator labii superioris muscle. The result is a more balanced, aesthetically pleasing smile without excessive gum exposure. This treatment typically requires only a few units of Botox and offers a minimally invasive option for smile enhancement.

Botox for Neck and Décolletage Lines

The platysma muscle is a thin, sheet-like muscle that extends from the collarbone up to the jawline. Over time, repetitive movements and natural aging can cause this muscle to form vertical bands, contributing to an aged appearance of the neck and jawline. Botox injections into the platysma muscle can relax these bands, resulting in a smoother and more youthful neck contour.

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In October 2024, the FDA approved Botox Cosmetic (onabotulinumtoxinA) for the temporary improvement in the appearance of moderate to severe platysma bands in adults. This approval was largely based on a randomized, double-blind, placebo-controlled phase 3 trial, which demonstrated significant improvement in platysma band severity at maximum contraction compared with placebo. The approved treatment involves injecting Botox into specific points along the platysma bands, with dosages tailored to the severity of the bands.

By targeting the platysma muscle, Botox not only smooths vertical neck bands but also enhances the definition of the jawline. This treatment offers a non-surgical option for individuals seeking to rejuvenate the neck and décolletage area, providing noticeable results with minimal downtime.

Botox for Underarm Sweating (Hyperhidrosis Treatment)

Excessive sweating, also known as hyperhidrosis, can be both uncomfortable and embarrassing, especially when it affects areas like the underarms. Fortunately, Botox is FDA-approved for treating hyperhidrosis in the underarm region, offering an effective solution for those seeking relief. The treatment works by blocking the chemical signals from the nerves that activate sweat glands, significantly reducing sweat production.

The procedure is highly standardized, involving 100 units of Botox, 50 units injected into each underarm. These injections are placed across the area to directly target the sweat glands and inhibit their activity. Most patients begin to notice a substantial reduction in sweating within just a few days after treatment, with full results typically visible within two weeks. The effects of Botox for hyperhidrosis generally last between six and nine months, making it a long-term solution for managing excessive sweating.

For many, this treatment is life-changing, providing greater comfort and confidence in everyday situations without the constant worry of sweat stains or odor.

Botox for Hands and Feet: Treating Excessive Sweating and Wrinkles

Botox is widely recognized for its cosmetic applications, but it also offers effective solutions for conditions like hyperhidrosis (excessive sweating) and signs of aging in the hands and feet.

Treating Hyperhidrosis in Hands and Feet

Excessive sweating in the palms (palmar hyperhidrosis) and soles (plantar hyperhidrosis) can significantly impact daily activities and self-confidence. Botox injections can alleviate these symptoms by blocking the nerve signals that stimulate sweat glands. This treatment has been shown to reduce sweating in these areas, providing relief for several months.

Hand Rejuvenation

The hands often reveal signs of aging, such as wrinkles and volume loss. Botox can be used to smooth out fine lines and improve the overall appearance of the hands. By relaxing the muscles that contribute to wrinkles, Botox helps restore a more youthful look.

Foot Rejuvenation

While less common, Botox can also be applied to the feet to address issues like excessive sweating and discomfort from high heels. By targeting specific muscles, Botox can provide relief and improve comfort in the feet.

Tips for Choosing the Right Botox Injection Sites

1. Understanding Your Facial Structure: Where Botox Works Best

Each individual’s facial anatomy is unique, and effective Botox treatment requires a personalized approach. Factors such as muscle strength, skin elasticity, and aesthetic goals influence the selection of injection sites. A thorough consultation with a qualified practitioner ensures that Botox is administered in areas that will achieve the desired results while maintaining natural expressions.

2. Choose a Qualified Injector Why Experience Matters

When it comes to Botox, the skill and experience of your injector are critical to achieving safe, natural-looking results. Botox administration requires a deep understanding of facial anatomy and precision in technique. An experienced provider knows the exact muscle groups to target and how much product is needed to achieve the desired effect without compromising facial expressions.

A qualified injector will also have a strong understanding of how Botox interacts with different facial structures, which is essential for avoiding complications like drooping eyelids or uneven results. During your consultation, it is a good idea to ask about their experience, certifications, and even request before-and-after photos of their work. At a reputable clinic, your safety and satisfaction should always be the top priorities.

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Read more: What Kind of Doctor Administers Botox?

What to Expect Before During and After

Preparing for your Botox appointment helps ensure the best possible outcome and minimizes the risk of side effects. Here’s what you can expect:

Before Treatment:

  • Avoid blood-thinning medications such as aspirin, ibuprofen, or supplements like fish oil for a week prior to your appointment to reduce the risk of bruising.
  • Limit alcohol consumption for at least 24 hours before treatment.
  • If you are prone to cold sores and are receiving injections around the mouth, inform your provider as you may need antiviral medication as a preventive measure.

During Treatment:

  • The procedure itself typically takes about 15 to 25 minutes, depending on the number of areas being treated.
  • A very fine needle is used to inject Botox into targeted muscles. You may feel a small pinch, but discomfort is generally minimal.
  • Numbing cream or ice packs can be applied if you are particularly sensitive to injections.

After Treatment:

  • Avoid touching, rubbing, or massaging the treated areas for at least 4 hours.
  • Remain upright and avoid lying down for at least 4 hours post-treatment to prevent product migration.
  • Skip heavy exercise and saunas for the first 24 hours to avoid increased blood flow to the injection sites.
  • Minor redness, swelling, or bruising may occur but should subside within a few days.

Potential Risks and Side Effects of Botox Injections

Botox is generally considered safe and well-tolerated, but like any medical treatment, it can come with some temporary side effects. The most common ones include mild bruising, redness, and swelling at the injection site. These reactions are typically minor and subside within a few days. Applying a cold compress and avoiding blood-thinning medications like aspirin and ibuprofen before your appointment can help minimize the risk of bruising.

Some patients may also experience mild headaches after treatment, especially if Botox is administered in the forehead or brow area. These headaches are generally short-lived and can be managed with over-the-counter pain relievers, such as acetaminophen. Another common effect is slight tenderness around the injection sites, which usually fades within a day or two.

To further reduce side effects, it is recommended to avoid heavy exercise, alcohol consumption, and excessive sun exposure for 24 hours after your session. Following proper aftercare instructions ensures a smoother recovery and helps maintain your results.

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How Botox Injection Sites Vary by Age Skin Type and Treatment Goals

Botox Injection Sites for Different Age Groups Tailored Treatment

The areas treated with Botox and the amount required can vary significantly based on a person’s age, skin type, and aesthetic goals. For younger clients, Botox is often used as a preventive measure, targeting fine lines before they deepen into wrinkles. Common injection sites for younger patients include the forehead and crow’s feet, with smaller amounts of Botox used to maintain a natural appearance.

For those in their 40s and beyond, Botox may be used more extensively to address established lines and more widespread wrinkles. In these cases, injection sites often include the glabellar lines (frown lines), forehead, crow’s feet, and sometimes around the mouth and jawline. The treatment plan may also incorporate a slightly higher number of units to effectively smooth out deeper wrinkles.

Additionally, the approach to Botox varies with skin type. For individuals with thinner skin, lower doses are often used to prevent a frozen look, while those with thicker or more resilient skin may require slightly more product to achieve the desired smoothing effect. A personalized consultation ensures the treatment is customized to your unique facial structure, skin condition, and aesthetic goals.

Skin Type and Botox Adjusting Injection Sites for Optimal Results

The effectiveness and safety of Botox treatments can vary depending on your skin type. Hydration levels in the skin can influence how the Botox settles and how long it lasts, so your provider may recommend moisturizing and proper skincare both before and after your appointment.

For oily or acne-prone skin, Botox can sometimes help reduce oil production in treated areas. Injection sites may be carefully selected to avoid aggravating clogged pores or sensitive spots. Additionally, individuals with sensitive skin may experience more redness or mild irritation after treatment. Using soothing post-treatment products like gentle cleansers and avoiding harsh exfoliants can help minimize discomfort.

Sensitive skin types may also require smaller amounts of Botox to prevent unnecessary irritation. In these cases, your provider will place injections to achieve the desired effect without triggering sensitivity.

Final Thoughts

Choosing the right Botox injection sites and understanding how factors like age, skin type, and lifestyle influence your results is essential for achieving your aesthetic goals. At ZENA Aesthetics & Wellness in Bradenton, FL, our team takes the time to understand your unique needs and design a treatment plan tailored specifically to you. With the right approach, Botox can help you achieve a youthful, refreshed look with natural results.

FAQs

1. What are the proper Botox injection sites?

The proper Botox injection sites depend on the areas you want to treat. Common areas include the forehead, crow’s feet, glabellar lines, and around the mouth and jawline. Your injector will assess your facial structure to determine the ideal locations for the best results.

2. What is the 2 cm rule for Botox?

The “2 cm rule” is a guideline for safely injecting Botox around the eyes, especially for treating crow’s feet. It suggests that injections should be placed at least 2 centimeters away from the orbital rim, which is the bony edge around the eye socket. This helps prevent Botox from affecting deeper muscles that control eye movement, reducing the risk of drooping or other side effects.

3. What are the top 3 areas for Botox?

The three most popular areas for Botox are the forehead to smooth horizontal lines, the glabellar lines (frown lines) between the eyebrows, and the crow’s feet around the eyes. These are the most common spots for first-time Botox patients seeking to reduce visible signs of aging.

4. Where should Botox not be injected?

Botox should not be injected into areas that could interfere with natural muscle function, like the lower eyelids or certain spots near the mouth that control essential facial expressions. It should also be avoided in areas with active skin infections, irritation, or unhealed wounds. An experienced injector will know which areas to avoid to maintain facial balance and natural expressions.

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Dr. Dylan Cahill, MD

Dr. Dylan Cahill is the co-owner of ZENA Aesthetics & Wellness, where he leads the practice in offering advanced non-surgical aesthetics and wellness services. As a graduate of Harvard Medical School, Dylan combines his knowledge of longevity science with a passion for personalized skincare and innovative treatments. He manages a team of skilled professionals dedicated to delivering personalized care and exceptional outcomes. His expertise spans medical spa treatments, anti-aging therapies, and strategic growth in the health and wellness industry.

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