Xeomin vs Botox: Is Xeomin Better Than Botox?

When it comes to reducing wrinkles and smoothing out fine lines, there are several options available, each with its own subtle distinctions. Anti-wrinkle treatments have become popular for their ability to offer a refreshed look without invasive procedures. Neuromodulators like Botox are often used as a general term for wrinkle-reducing treatments, but technically, Botox refers to the well-established brand, Botox Cosmetic. Both Botox Cosmetic and Xeomin deliver similar results through slightly different formulations.

These treatments work by temporarily relaxing the muscles that cause wrinkles, particularly around the eyes, forehead, and mouth. While Botox Cosmetic has been around longer and is more widely known, Xeomin has gained popularity as a highly effective alternative. Many clinics may offer one but not the other, or sometimes both, as they both provide noticeable results with minimal downtime.

The differences between them can be subtle, but understanding these distinctions can help you make the best choice for your needs. Let’s explore what sets these treatments apart so you can be informed heading into your aesthetics consultation.

7 Main Differences Between Xeomin and Botox Cosmetic

While Botox Cosmetic and Xeomin are both effective in reducing wrinkles, they differ in their formulas, timing, and range of uses. Knowing these differences can help you decide which option might be better suited for your needs.

1. Xeomin is a “Naked” Injectable

Xeomin is sometimes called a “naked” injectable because it contains only the active ingredient, botulinum toxin type A, without any “accessory proteins.” Accessory proteins are extra proteins that surround the active ingredient (botulinum toxin type A) in Botox Cosmetic to help stabilize it, but they don’t play a role in wrinkle reduction. Xeomin’s simplified formula with just the active ingredient can be gentler for some people, as there are fewer components for the body to interact with.

2. Xeomin May Reduce Antibody Formation

Since Xeomin doesn’t contain accessory proteins, it may lower the risk of developing antibodies against the treatment. Antibodies are part of the body’s defense system and, in rare cases, they can start recognizing Botox Cosmetic (including its accessory proteins) and block its effects. Xeomin’s pure formula without these extra proteins may reduce this risk, making it a possible option for people who’ve noticed Botox Cosmetic becoming less effective over time. However, it’s worth noting that this reduced antibody formation is more theoretical than definitive—most people tolerate Botox Cosmetic well and don’t experience a loss of effectiveness.

3. Botox Cosmetic Usually Takes 3-5 Days to Show Results

Both Botox Cosmetic and Xeomin take a few days to start working, but the timing can vary slightly. Botox Cosmetic typically takes 5-7 days to show results, and Xeomin might take around the same time, though some individuals may find results start slightly earlier or later. Both treatments reach their peak effect within two weeks, giving a refreshed, smooth look that lasts for several months.

4. Botox Cosmetic Has More FDA-Approved Uses

Both Botox Cosmetic and Xeomin are FDA-approved for treating frown lines between the eyebrows, but Botox Cosmetic has more approved medical uses. In addition to wrinkle reduction, Botox Cosmetic is also used to treat migraines, excessive sweating, and certain muscle-related issues. Xeomin remains focused on cosmetic treatments and is newer to the market, though both have been around for many years and are well-studied.

5. Xeomin Spreads Slightly Differently

Some patients and practitioners have noticed that Xeomin may spread slightly differently within the treated area compared to Botox Cosmetic. This difference in spread can influence how precise the results are, particularly in smaller or more targeted areas like crow’s feet around the eyes. Botox Cosmetic, with its added proteins, may stay more localized, while Xeomin’s “naked” formula could diffuse a bit more. This subtle difference can be something to consider based on which areas you’re hoping to treat.

6. Botox Cosmetic Has Been on the Market Longer

Botox Cosmetic has been available since the early 2000s and is widely recognized as the original wrinkle-relaxing injection. With years of patient outcomes and studies behind it, Botox Cosmetic is a trusted choice for many. Xeomin is newer but has quickly gained popularity, especially with patients looking for a “cleaner” formula without accessory proteins. While both are effective, Botox Cosmetic’s long-standing presence has made it a more familiar choice. Xeomin, however, offers an appealing alternative that, for some individuals, may provide benefits like longer-lasting effects or a subtly different result that better matches their preferences.

7. Areas that Botox Cosmetic and Xeomin Are Used

Botox Cosmetic and Xeomin are both commonly used to treat areas prone to wrinkles from facial expressions, such as the forehead, frown lines (between the eyebrows), and crow’s feet. Both are FDA-approved for these purposes, making them equally effective for reducing visible signs of aging in these areas.

In terms of unique uses, Botox Cosmetic is FDA-approved for several additional treatments beyond wrinkle reduction. It’s used to address migraines, excessive sweating (often in the underarms or palms), certain muscle spasms, and even jaw tension in some cases. Xeomin, in contrast, remains focused on cosmetic uses for facial wrinkles and hasn’t been approved for these broader medical applications.

Is Xeomin Safer Than Botox Cosmetic?

Both Xeomin and Botox Cosmetic are FDA-approved treatments, meaning they’ve both undergone rigorous testing to ensure their safety. Neither treatment is inherently “safer” than the other; however, Xeomin’s simplified formula without accessory proteins may make it a better option for those with sensitivities or concerns about added ingredients. By removing accessory proteins, Xeomin reduces the number of components that the body might react to, which in theory can offer an advantage for patients prone to sensitivities. That said, both treatments are considered safe when administered by a trained professional. Ultimately, discussing your health history and any concerns with your provider can help determine which option is best for you.

How Xeomin and Botox Cosmetic Treat Wrinkles

Neuromodulators like Xeomin and Botox Cosmetic work by targeting the muscles responsible for expression lines—those wrinkles that appear when we smile, frown, or squint. By temporarily relaxing these muscles, both treatments smooth out wrinkles, giving the face a softer, more refreshed look.

Xeomin vs Botox: Similarities and Differences

The key similarity between Xeomin and Botox Cosmetic is their active ingredient: both use botulinum toxin type A to achieve results. This neurotoxin temporarily blocks nerve signals to the treated muscles, relaxing them and reducing the appearance of wrinkles. Both treatments are injected similarly and show effects that last for several months.

The primary difference is in the formula. Botox Cosmetic contains accessory proteins that surround the active ingredient, while Xeomin’s “naked” formula includes only the botulinum toxin. This difference can slightly affect how each treatment spreads, how well it’s tolerated, and even the potential for developing resistance. For most people, both options work similarly, but Xeomin may be preferable for those with specific sensitivities or a history of reduced response to Botox Cosmetic.

Is Xeomin More Natural Than Botox Cosmetic?

In terms of how they work, both Xeomin and Botox Cosmetic are synthetic forms of botulinum toxin type A, so neither can be considered entirely “natural.” However, Xeomin’s formula is often described as “cleaner” or more purified due to the absence of accessory proteins. This simplified formula has led some to view Xeomin as a more straightforward, “natural” option compared to Botox Cosmetic.

If a minimal-ingredient approach resonates with you, Xeomin’s formulation might align more closely with that preference. However, the choice ultimately depends on personal priorities, as both treatments are synthetic yet designed to deliver effective, natural-looking results when used for wrinkle reduction.

What to Expect During Treatment

Both Xeomin and Botox Cosmetic treatments are relatively quick and easy. A typical appointment lasts about 15–45 minutes, depending on the extent of the area being treated, during which your provider will cleanse the area and may use a numbing cream to ensure comfort. Using a very fine needle, they’ll make a few small injections into the specific muscles responsible for wrinkles or other concerns. The experience is usually well-tolerated and doesn’t require any downtime, so most people can return to their day immediately afterward.

Aftercare Tips for Best Results

After treatment, it’s important to follow a few simple guidelines to get the best results. Avoid rubbing the treated area, engaging in intense physical activity, or lying down for at least the first four hours. Some providers recommend avoiding alcohol and excessive sun exposure on the day of treatment. Results typically begin to appear in a few days, and you’ll see full effects within two weeks. Regular follow-ups can help maintain a smooth, refreshed look.

Does Xeomin Last Longer Than Botox Cosmetic?

The duration of results is similar for both Xeomin and Botox Cosmetic, with effects typically lasting about 3–4 months, though this varies by individual. Certain factors like metabolism, lifestyle, and the specific area being treated can affect longevity. For best results, most people opt to have treatments done regularly, approximately every 3–4 months, to maintain a consistently smooth appearance.

Potential Results for Specific Concerns  

For concerns like an eyebrow lift or gummy smile correction, results can vary. Areas with more muscle movement, such as around the mouth, may see effects fade slightly faster. For concerns like forehead lines or crow’s feet, Xeomin and Botox Cosmetic can provide long-lasting smoothness. It’s best to discuss any specific goals with your provider to determine how often you may need touch-ups for different areas.

Xeomin vs Botox Cosmetic Price: Which Is More Affordable?

Generally, Xeomin is slightly more affordable than Botox Cosmetic due to differences in the manufacturing process and associated costs for clinics. However, many providers price them similarly, with a greater focus on the clinic experience and the injector’s skill, as both products offer inherently similar results.

Common Side Effects for Each

Xeomin and Botox Cosmetic have similar side effects, which are typically mild and temporary. These may include minor redness, swelling, or bruising at the injection site. Some people may experience mild headaches or a slight sensation of heaviness in the treated area, which usually resolves within a day or two.

Precautions for Pregnancy and Breastfeeding

For safety, neuromodulators like Xeomin and Botox Cosmetic are generally not recommended for those who are pregnant or breastfeeding. While there’s no conclusive evidence of harm, it’s best to be cautious. Always discuss any concerns with your provider if you’re considering treatment during these times.

Can You Combine Xeomin and Botox Cosmetic?

While it’s uncommon, combining Xeomin and Botox Cosmetic can be done in certain cases. Some people may prefer the unique spread of Xeomin in specific areas and the more localized effect of Botox Cosmetic in others. However, it’s generally more common to stick with one product for consistency. Individuals may switch from one to the other at some point to see if they achieve preferable results. Consulting with an experienced injector can help determine if a combined or alternative approach would be beneficial.

Is Xeomin Better Than Botox Cosmetic?

The answer to this question often comes down to personal preference rather than one product being outright “better” than the other. Botox Cosmetic and Xeomin are both effective, with the same active ingredient in slightly different formulations. An analogy might be choosing between two brands of mineral water—both hydrate you, but with slight variations in taste or mineral content.

Ultimately, the skill and experience of the injector matter more than the specific product. At ZENA Aesthetics & Wellness, our injector Dr. Inda Mowett has over 20 years of experience in aesthetics and guides patients through their options to find the right fit. During your consultation, we discuss the two neuromodulators our clinic current offers, Botox Cosmetic and Dysport, offering you a clear understanding of each option and helping you make the best choice based on your goals.

The Bottom Line

Both Xeomin and Botox Cosmetic offer effective solutions for smoothing wrinkles and refreshing your appearance. They share the same active ingredient, but with slight differences in formulation. While neither is definitively “better,” the decision ultimately comes down to personal preference, potentially one’s budget, and the advice of a trusted provider.

At ZENA Aesthetics & Wellness, we carry both Botox Cosmetic Cosmetic and Dysport, ensuring we can tailor treatments to your unique needs. Our injector’s 20+ years of experience in aesthetics means you’ll receive guidance on the best choice for you, with results that are natural-looking and suited to your goals.

FAQs

1. Is Xeomin better than Botox Cosmetic?

Neither is inherently better; they are simply different formulations of the same active ingredient. The best choice depends on your goals, preferences, and your provider’s recommendation.

2. Is 20 units of Xeomin the same as 20 units of Botox Cosmetic?

Yes, Xeomin and Botox Cosmetic units are generally equivalent, meaning 20 units of Xeomin would have a similar effect as 20 units of Botox Cosmetic.

3. Is Xeomin more natural-looking?

Both Xeomin and Botox Cosmetic provide natural-looking results when administered correctly. Xeomin’s simplified formula may appeal to those who prefer a “cleaner” product, but both can offer equally subtle outcomes.

4. Who should not use Xeomin?

Xeomin is not recommended for individuals who are pregnant, breastfeeding, or have certain neurological conditions. Always consult with a provider to ensure the treatment is safe for you.

5. Can I switch from Botox Cosmetic to Xeomin?

Yes, many people switch between Botox Cosmetic and Xeomin without issue. Xeomin may be a good option for those who feel they’ve built up resistance to Botox Cosmetic or simply want to try a different formulation.

6. How long do you have to stay upright after Xeomin?

It’s generally recommended to stay upright for at least 4 hours after a Xeomin treatment. This helps prevent the product from moving into unintended areas, ensuring optimal results.

7. Why can’t you exercise after Xeomin?

Strenuous exercise increases blood flow and can potentially cause Xeomin to migrate from the treated area, which could reduce its effectiveness or lead to uneven results. Waiting 24 hours before returning to your regular workout routine is advised.

8. What should I avoid after Xeomin?

After Xeomin, avoid touching or massaging the treated area, engaging in intense physical activities, and exposing the area to excessive heat, such as saunas or hot tubs, for at least 24 hours. These precautions help ensure that the treatment settles correctly.

9. Can you use retinol with Xeomin?

While retinol can generally be used in conjunction with Xeomin, it’s best to avoid applying retinol or other strong skincare products immediately after the treatment to prevent irritation. Waiting 24–48 hours before resuming your skincare routine is often recommended.

10. What not to eat or drink before Botox Cosmetic?

Before Botox Cosmetic, it’s wise to avoid alcohol, as it can increase the likelihood of bruising. Foods high in vitamin E, such as nuts and fish, and certain medications, like aspirin, can also increase bruising risk. If you’re unsure, consult your provider for specific recommendations.

11. Does caffeine affect Botox Cosmetic?

Caffeine doesn’t directly affect Botox Cosmetic, but because it can increase heart rate and blood pressure, it might contribute to mild bruising. Limiting caffeine on the day of treatment may help minimize this risk.

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